STORY AT-A-GLANCE
- Cats brought to the veterinarian for vague symptoms are sometimes described as “ain’t doing right,” or ADR cases
- In cats age 10 and older, common causes of ADR include oral disease, kidney disease, joint disease, hyperthyroidism, diabetes and cancer
- Changes like eating less, moving differently, hiding more or seeming “off” may look minor, but they can point to significant disease in older cats
- Many age-related conditions can be helped through earlier diagnosis, supportive care, dietary changes and therapies aimed at improving comfort and quality of life
- Cat parents can also lower risk over time by focusing on prevention, including good nutrition, dental care, healthy weight and regular veterinary checkups

Editor's Note: This article is a reprint. It was originally published May 28, 2015.
Have you ever thought something was a little "off" with your cat but you couldn't quite pinpoint it? Perhaps she was eating less, sleeping more, or avoiding you. Or she was sitting or lying in an awkward position, or her movements were halting or hesitant.
At some veterinary clinics, these cases are referred to as "Ain't doing right," or ADR, to describe nonspecific symptoms that may or may not indicate an underlying disease.
In cats 10 and older, the most frequent causes of ADR are different than those seen in younger kitties. They include oral disease, kidney disease, degenerative joint disease, hyperthyroidism, diabetes mellitus, and cancer.
Oral Disease in Older Cats
Diseases of the mouth, including gum disease, exposed roots, tooth resorption, stomatitis, and oral masses are common in cats of all ages, and particularly older kitties. The pain associated with many of these conditions can negatively impact your pet's quality of life, and also contributes to lack of interest in eating and weight loss.
Daily tooth brushing and professional cleanings by your veterinarian if required are the best way to keep your cat's mouth healthy and disease-free. They are also important for pets with chronic conditions such as diabetes, heart disease, and kidney failure.
Veterinary dental cleanings require general anesthesia, because a thorough oral exam and cleaning can't be accomplished on a kitty who is awake. It's dangerous to use sharp instruments in the mouth of a conscious animal, not to mention the procedure is extremely stressful for the cat.
Many people believe their cat is simply too old for anesthesia — this is a very common misconception among cat guardians. Age itself is not a disease, so if your pet is otherwise healthy, his age won't increase his risk of anesthetic complications as long as your vet has up-to-date, advanced anesthetic monitoring equipment, and is using the correct anesthesia protocols for your senior cat.
Chronic Kidney Disease
Chronic kidney disease (CKD) is all too common in older kitties. Studies show that over half of cats 7 years or older have CKD, and between 70% and 80% of cats 10 and older have the disease. Once CKD is diagnosed, it is irreversible and can be difficult to manage. Treatment is supportive and involves trying to slow the progression of the disease through dietary changes, fluid injections, and other therapies.
To help prevent CKD, feeding high-quality protein in its natural, unadulterated form (canned or raw food) as soon as a kitten is weaned is recommended. This provides a moisture-rich diet for the cat's lifetime, which helps reduce stress on the kidneys.
In kitties already diagnosed with kidney disease, a diet high in excellent quality protein and lower than normal amounts of sodium and phosphorus is recommended.
Cats with kidney disease do best eating high-quality, human grade canned food or a fresh, balanced homemade diet. If your CKD kitty is still eating kibble, switching to a moisture-rich diet, if possible, is worth considering to help nourish the kidneys. Most importantly, cats with kidney disease should continue to eat, and unlimited access to fresh water should always be provided.
Degenerative Joint Disease
In a study of 100 cats 12 years of age or older, as many as 90% had degenerative joint disease (DJD), with the elbow being the most common location. DJD causes chronic pain in kitties that their guardians often don't notice or write off to normal aging.
Specific signs to watch for include reduced activity, difficulty jumping, lameness, and hair loss at the affected joint due to over-grooming. Kitties in pain from DJD may also lose their appetite, eliminate outside the litterbox, be irritable or aggressive, and less social.
Unfortunately, because cats are so physiologically unique, there are very few safe, effective pharmaceutical pain relievers that can be given long-term to control chronic conditions like DJD.
There are a number of things you can do to alleviate your kitty's pain and improve mobility. These include chiropractic, therapeutic massage, cat stretches, acupuncture, prolotherapy, the Assisi Loop (a form of pulsed electromagnetic field therapy), and laser therapy.
There are also certain supplements you can try adding to your cat's diet that provide the raw materials for cartilage repair and maintenance, including glucosamine sulfate, perna mussel, MSM and egg shell membrane; homeopathics, based on your kitty's symptoms, but may include Rhus Tox, Bryonia, and Arnica; ubiquinol; turmeric; spirulina and astaxanthin; natural anti-inflammatory formulas such as proteolytic enzymes; EFAC complex; and krill oil.
Working with a holistic veterinarian is recommended to determine how to best treat inflammation and pain, as well as how to nourish remaining cartilage.
Hyperthyroidism
Feline hyperthyroidism has reached epidemic proportions in the U.S., with over 10% of kitties over the age of 10 diagnosed with the disease. About half the cats that develop hyperthyroidism have an increase in appetite. About 90% ultimately lose weight because the disease causes an increase in metabolism rates.
Other symptoms include high blood pressure, frequent vomiting, increased body temperature, heart and respiration rates, and hyperactivity. A combination of increased appetite, weight loss and sudden, unexpected bursts of energy in an older cat is a sign you might have a kitty with hyperthyroidism. Make an appointment with your veterinarian as soon as possible. The disorder can be diagnosed with a simple blood test. To help prevent thyroid disease in your kitty:
- Feed a balanced, preferably raw, species-appropriate diet. If you prepare a balanced, homemade diet for your cat, you have complete control over iodine levels in your pet's food. Iodine levels in cat diets have been linked to hyperthyroidism.
- Avoid feeding your cat a fish-based diet. Seafood is a very rich source of iodine, but cats aren't designed to process a lot of iodine.
- Also avoid feeding soy products to your kitty, as they have been linked to thyroid damage.
- Rid your environment of flame retardant chemicals (polybrominated diphenyl ethers, or PBDEs). There have been studies have linking these chemicals in house dust to the growing problem of thyroid disease in pet cats.
Checking a cat's thyroid levels annually after age 10 is also recommended.
Diabetes
Diabetes mellitus is another all-too-common disease of older cats, and is especially prevalent in kitties fed carbohydrate-based dry food diets.
Unfortunately, many veterinarians continue to recommend commercial or "prescription" diets for diabetic cats. These foods typically contain a small amount of rendered protein and a tremendous amount of fiber. A diet deficient in high-quality protein will force a cat's body to metabolize its own muscle, which contributes to muscle loss and the rear limb weakness characteristic of diabetic neuropathy.
The ideal nutrition for cats is whole, fresh, unprocessed animal meat, organs and bones, with a small amount of veggies. Unfortunately, since most older cats with diabetes have spent their lives eating processed commercial pet food — typically kibble — it can be an insurmountable challenge to transition a sick kitty with little or no appetite to a new diet.
If this is the case with your cat, adding as much grain/potato-free canned cat food as possible to your pet's normal fare is recommended. The important thing is to ensure your kitty is eating well each day, and if that means continuing to feed dry cat food, that's what should be done. Just make sure to also encourage him to eat some canned food for the added protein and moisture it provides. With proper treatment (which almost always includes dietary changes), many diabetic cats can achieve remission.
Another big contributor to feline diabetes is obesity. Pets become overweight through a combination of an inappropriate diet, lack of portion control, and not enough calorie-burning physical activity. If you want to do everything possible to prevent diabetes in your pet, you should focus on keeping your kitty lean.
Cancer
Malignant neoplasms, including extranodal lymphoma (lymphoma that is external to lymph nodes), mammary carcinoma, and squamous cell carcinoma of the mouth or skin, are common in aging kitties.
To help your cat avoid cancer, it's important not to expose her to cigarette smoke. Studies link secondhand smoke to a significantly increased risk of malignant lymphoma and oral squamous cell carcinoma in kitties.
Cats should not receive annual vaccines because unnecessary vaccines introduce antigenic adjuvants that contain heavy metals which can cause immune system imbalances in cats over time.
Studies also show that obesity increases cancer risk, so it's important to keep your cat lean and fit throughout his life.
Inflammation plays a role in cancer development. Diet is a primary factor, with high-carbohydrate diets considered pro-inflammatory for cats. A great diet for prevention supports healthy cells and repair, emphasizing organic, preservative-free foods and avoiding GMOs and processed carbohydrates.
Since carbs are pro-inflammatory nutrients that feed cancer cells, you'll want to avoid feeding your cat processed grains, fruits with fructose, and starchy vegetables like potatoes.
Cancer cells generally can't use dietary fats for energy, so appropriate amounts of good quality fats are nutritionally healthy.
As with any disease process, we want to diagnose cats with cancer as early as possible so that a treatment plan and/or palliative care can be initiated to help the kitty live as long as possible and with a good quality of life.